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226319

Sigma-Aldrich

Ethyl isocyanoacetate

95%

Synonym(s):

α-Isocyanoacetic acid ethyl ester, (Ethoxycarbonyl)methyl isonitrile, 2-Ethoxy-2-oxoethyl isocyanide, 2-Ethyloxycarbonylmethyl isocyanide, Ethoxycarbonylmethyl isocyanide, Ethyl α-isocyanoacetate, Ethyl 2-isocyanoacetate, Isocyanoacetic acid ethyl ester

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About This Item

Linear Formula:
CNCH2COOCH2CH3
CAS Number:
2999-46-4
Molecular Weight:
113.11
Beilstein:
3588613
EC Number:
221-077-9
MDL number:
MFCD00000007
UNSPSC Code:
12352100
PubChem Substance ID:
24853557
NACRES:
NA.22

Assay

95%

form

liquid

refractive index

n20/D 1.418 (lit.)

bp

194-196 °C (lit.)

density

1.035 g/mL at 25 °C (lit.)

functional group

amine
ester
isonitrile

storage temp.

2-8°C

SMILES string

CCOC(=O)C[N+]#[C-]

InChI

1S/C5H7NO2/c1-3-8-5(7)4-6-2/h3-4H2,1H3

InChI key

FPULFENIJDPZBX-UHFFFAOYSA-N

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General description

Ethyl isocyanoacetate is an isocyanide ester that serves as a building block for the production of heterocycles.

Application

Ethyl isocyanoacetate was used in the synthesis of 7-aza-tetrahydroindoles. It was also used to prepare pyrroles, oxazolines, benzodiazepines, oxazoles and imidazoles.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H332

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

183.2 °F - closed cup

Flash Point(C)

84 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBL1708
STBJ3749
STBH6685
STBH2264
STBG8437

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Marcus Baumann et al.
Organic letters, 8(23), 5231-5234 (2006-11-03)
[Structure: see text] A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesis platform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured
Tetrahedron Letters, 34, 5463-5463 (1993)
Tetrahedron Letters, 35, 2493-2493 (1994)
Chikashi Kanazawa et al.
Journal of the American Chemical Society, 128(33), 10662-10663 (2006-08-17)
The copper-catalyzed reaction between two different isocyanides produces the corresponding heteroaromatization products, imidazoles, in good yields. The reaction proceeds most probably through the activation of the sp3 C-H bond in the isocyanides by a copper catalyst, followed by a [3
Yifei Li et al.
Chemical communications (Cambridge, England), 48(100), 12228-12230 (2012-11-13)
A novel and efficient route for the synthesis of 7-aza-tetrahydroindoles from N-aryl/alkyl-alkenoylacetamides and ethyl isocyanoacetate is described. A mechanism, involving a stepwise [3+2] cycloaddition-intramolecular aza-Michael addition cascade, is proposed that explains the origin of the double nucleophilic attack on the
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