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U6885

Sigma-Aldrich

Uridine-5′-diphosphoglucose Dehydrogenase from Streptococcus pyogenes

recombinant, expressed in E. coli, Type VI, lyophilized powder

Synonym(s):

UDP-glucose:NAD+ 6-oxidoreductase

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About This Item

Enzyme Commission number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54

recombinant

expressed in E. coli

Quality Level

type

Type VI

Assay

≥95% (SDS-PAGE)

form

lyophilized powder

mol wt

~47 kDa

shipped in

dry ice

storage temp.

−70°C

Unit Definition

One unit will oxidize 1.0 μmole of UDP-glucose to UDP-glucuronic acid per minute at pH 8.7 at 25 °C.

Physical form

Lyophilized powder containing ~70% PBS and ~20% sorbitol.

Preparation Note

Animal component free

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Annastasia S Hyde et al.
The Journal of biological chemistry, 288(49), 35049-35057 (2013-10-23)
UDP-glucose dehydrogenase (UGDH) provides precursors for steroid elimination, hyaluronan production, and glycosaminoglycan synthesis. The wild-type UGDH enzyme purifies in a hexamer-dimer equilibrium and transiently undergoes dynamic motion that exposes the dimer-dimer interface during catalysis. In the current study we created
Simone Superina et al.
Developmental biology, 387(2), 154-166 (2014-01-28)
Growth factors and morphogens regulate embryonic patterning, cell fate specification, cell migration, and morphogenesis. The activity and behavior of these signaling molecules are regulated in the extracellular space through interactions with proteoglycans (Bernfield et al., 1999; Perrimon and Bernfield 2000;
Haifeng Li et al.
Applied biochemistry and biotechnology, 178(6), 1141-1153 (2015-11-29)
UDPG pyrophosphatase (UGPase) plays an important role in carbohydrate metabolism, catalyzing a reversible production of uridine diphosphate glucose (UDPG) and pyrophosphate (PPi) from Glc-1-P and UTP. UGPase gene from Aureobasidium pullulans NRRL Y-12974 was cloned, overexpressed in Escherichia coli. The

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