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SAB4504642

Sigma-Aldrich

Anti-phospho-RIPK2 (pSer176) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CARD3, Anti-CARDIAK, Anti-CCK, Anti-GIG30, Anti-RICK, Anti-RIP2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 61 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

O43353

UniProt accession no.

O43353

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer176)

Gene Information

human ... RIPK2(8767)

General description

Receptor interacting protein kinase 2 (RIP2K) has an N-terminal dual-specificity ser/tyr kinase domain. This gene is a member of the TKL kinase family (tyrosine kinase-like). RIP2K is located on human chromosome 8q21.

Immunogen

The antiserum was produced against synthesized peptide derived from human RIPK2 around the phosphorylation site of Ser176.

Immunogen Range: 146-195

Biochem/physiol Actions

Receptor interacting protein kinase 2 (RIP2K) can act as a new target for anti-inflammatory drugs. This gene participates in multiple nuclear factor-κB (NFκB) activation pathways and human colon tumorigenesis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation
Pellegrini E, et al.
PLoS ONE, 12(5) (2017)
Genetics of inflammasome-associated disorders: a lesson in the guiding principals of inflammasome function
Rodrigue-Gervais IG and Saleh M
European Journal of Immunology, 40(3), 643-648 (2010)
Receptor-interacting protein 2 (RIP2) gene polymorphisms are associated with increased risk of subclinical atherosclerosis and clinical and metabolic parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican study
Posadas-Sanchez R, et al.
Experimental and Molecular Pathology, 102(1), 1-6 (2017)
Ravi Bharadwaj et al.
Immunity, 56(5), 998-1012 (2023-04-29)
Cytosolic innate immune sensing is critical for protecting barrier tissues. NOD1 and NOD2 are cytosolic sensors of small peptidoglycan fragments (muropeptides) derived from the bacterial cell wall. These muropeptides enter cells, especially epithelial cells, through unclear mechanisms. We previously implicated
Huisheng Liu et al.
Journal of virology, 93(11) (2019-03-22)
The role of nucleotide-binding oligomerization domain 2 (NOD2) in foot-and-mouth disease virus (FMDV)-infected cells remains unknown. Here, we showed that FMDV infection activated NOD2-mediated beta interferon (IFN-β) and nuclear factor-κB (NF-ĸB) signaling pathways. NOD2 inhibited FMDV replication in the infected
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