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Key Documents

SAB3500010

Sigma-Aldrich

Anti-FNIP2 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution, ab2

Synonym(s):

Anti-FNIPL, Anti-Folliculin interacting protein 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FNIP2(57600)

General description

Folliculin interacting protein 2 (FNIP2) is a 125.6kDa protein expressed in the cytoplasm.

Immunogen

FNIP2 antibody was raised against an 18 amino acid peptide near the amino terminus of human FNIP2.

Biochem/physiol Actions

Folliculin interacting protein 2 (FNIP2) induces apoptosis. It associates with AMP-activated protein kinase (AMPK) and folliculin (FLCN). The protein also has a role in the O6-methylguanine-induced apoptosis signaling pathway.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship. Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500010.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Product No.
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Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O6-methylguanine-induced apoptosis.
Sano S
Biochemical and Biophysical Research Communications (2013)
A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA.
Komori K
Oncogene (2009)
Leeanna El-Houjeiri et al.
The Journal of clinical investigation, 131(22) (2021-11-16)
Growing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. The folliculin (FLCN) tumor suppressor complex (FLCN, FNIP1, FNIP2) is implicated in the regulation of energy homeostasis via

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