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R3280

Sigma-Aldrich

Monoclonal Anti-RPA/p70 antibody produced in mouse

~1.5 mg/mL, clone 2H10, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Monoclonal Anti-REPA1, Monoclonal Anti-RF-A, Monoclonal Anti-RP-A, Monoclonal Anti-RPA70, Monoclonal Anti-hSSB, Monoclonal Anti-replication protein A1, 70kDa

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2H10, monoclonal

form

buffered aqueous solution

mol wt

antigen ~70 kDa

species reactivity

human

concentration

~1.5 mg/mL

technique(s)

immunocytochemistry: suitable
western blot: 1-2 μg/mL using HeLa total cell extract

isotype

IgG1

UniProt accession no.

P27694

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RPA1(6117)

Immunogen

purified human RPA/p70.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M A Serrano et al.
Oncogene, 32(19), 2452-2462 (2012-07-17)
Homologous recombination (HR) and nonhomologous end joining (NHEJ) are two distinct DNA double-stranded break (DSB) repair pathways. Here, we report that DNA-dependent protein kinase (DNA-PK), the core component of NHEJ, partnering with DNA-damage checkpoint kinases ataxia telangiectasia mutated (ATM) and
Yan Wang et al.
Neurotoxicity research, 25(2), 193-207 (2013-09-03)
Dopamine β-hydroxylase (DBH) and norepinephrine (NE) transporter (NET) are the noradrenergic phenotypes for their functional importance to noradrenergic neurons. It is known that in vivo N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) treatment induces degeneration of noradrenergic terminals by interacting with NET and depleting intracellular
M K Kenny et al.
The Journal of biological chemistry, 265(13), 7693-7700 (1990-05-05)
Human single-stranded DNA binding protein (human SSB) is a multisubunit protein containing polypeptides of 70, 34, and 11 kDa that is required for SV40 DNA replication in vitro. In this report we identify the functions of the SSB and its
Emanuela Grassilli et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(14), 3820-3831 (2013-06-05)
Evasion from chemotherapy-induced apoptosis due to p53 loss strongly contributes to drug resistance. Identification of specific targets for the treatment of drug-resistant p53-null tumors would therefore increase the effectiveness of cancer therapy. By using a kinase-directed short hairpin RNA library

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