R121

S(−)-Raclopride (+)-tartrate salt

>97%, solid

• Synonym(s): 3,5-Dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-6-methoxybenzamide (+)-tartrate salt
• Empirical Formula (Hill Notation): C₁₅H₂₀Cl₂N₂O₃ · C₄H₆O₆
• CAS Number: 98185-20-7
• Molecular Weight: 497.32
• MDL number: MFCD00274072
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277931
• NACRES: NA.77

Properties

• Assay: >97%
• form: solid
• color: white
• solubility: H₂O: 89 mg/mL
• SMILES string: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC
• InChI: 1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1
• InChI key: QULBVRZTKPQGCR-NDAAPVSOSA-N
• Gene Information: human ... DRD2(1813)

Description

Application

S(−)-Raclopride (+)-tartrate salt has been used as a D2 receptor antagonist:

• to study the role of the D2 receptor in mediating ventrolateral PAG (vlPAG)/dorsal raphe dopaminergic antinociceptive effect in animals
• in pharmacological and behavioral studies performed with Thap1 null mice
• to determine the relationship between Ca²⁺ transients and dopamine neuron activity in rats

Biochem/physiol Actions

Raclopride is a benzamide derivative and a selective D2 dopamine receptor antagonist.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Caution

Photosensitive

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves