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I3282

Sigma-Aldrich

Monoclonal Anti-Interleukin-10 Receptor α antibody produced in mouse

clone 37607, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-IL-10 Receptor α

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About This Item

MDL number:
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

37607, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

neutralization: suitable

isotype

IgG1

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL10RA(3587)

General description

Interleukin-10 (IL-10) is a pleotropic cytokine with anti-inflammatory and immunosuppressive functions. It is the key cytokine that regulates the host inflammatory responses to bacterial, fungal and viral pathogens. IL-10 is secreted by a variety of cells including T cells, B cells, dendritic cells, eosinophils, natural killer cells and mast cells. The effects of IL-10 are mediated by binding to the IL-10R, consisting of α and β subunits. The signalling through IL-10R activates Jak1, Tyk2 protein kinases and JAK/STAT3 pathways. IL-10R is involved in suppression of innate immunity to kill pathogens and inhibits the release of reactive oxygen and nitrogen species from activated macrophages. Regulation of IL-10R mediated signalling is important in infections, inflammatory responses in autoimmune encephalomyelitis, endotoxic shock and chronic enterocolitis
Monoclonal Anti-Interleukin-10 Receptor α (IL-10 Rα) recognizes human IL-10 Rα. The antibody does not cross-react with recombinant mouse IL-10 Ra.

Specificity

The antibody has the ability to block cell surface human IL-10 Rα mediated bioactivity induced by recombinant human IL-10. The antibody does not cross-react with mouse IL-10 Rα.

Immunogen

purified recombinant human IL-10 soluble receptor α expressed in insect Sf 21 cells.

Application

Anti-interleukin-10 receptor α antibody is suitable for neutralization reactions (ND50 is 0.03-0.1 μg/ml).

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Christian M Hedrich et al.
Immunologic research, 47(1-3), 185-206 (2010-01-21)
IL-10 plays an essential part in controlling inflammation and instructing adaptive immune responses. Consequently, dysregulation of IL-10 is linked with susceptibility to numerous infectious and autoimmune diseases in mouse models and in humans. It has become increasingly clear that appropriate
Joshua C Cyktor et al.
Infection and immunity, 79(8), 2964-2973 (2011-05-18)
The generation of an effective immune response against an infection while also limiting tissue damage requires a delicate balance between pro- and anti-inflammatory responses. Interleukin-10 (IL-10) has potent immunosuppressive effects and is essential for regulation of immune responses. However, the
K W Moore et al.
Annual review of immunology, 19, 683-765 (2001-03-13)
Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be
Yan Zhang et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 30(3), 113-122 (2010-03-02)
Apoptosis and the rapid clearance of apoptotic cells (ACs) by professional or nonprofessional phagocytes are normal and coordinated processes that ensure controlled cell growth and stress response with nonpathological outcomes. Uptake of ACs by phagocytes is thought to suppress autoimmune
Ivan J Fuss et al.
Journal of immunology (Baltimore, Md. : 1950), 168(2), 900-908 (2002-01-05)
In the present study, we define the relation between TGF-beta and IL-10 in the regulation of the Th1-mediated inflammation occurring in trinitrobenzene sulfonic acid (TNBS)-colitis. In initial studies, we showed that the feeding of trinitrophenol-haptenated colonic protein to SJL/J mice

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