D2629

6-(Dimethylamino)purine

≥98%

• Synonym(s): 6-DMAP, N⁶,N⁶-Dimethyladenine
• Empirical Formula (Hill Notation): C₇H₉N₅
• CAS Number: 938-55-6
• Molecular Weight: 163.18
• Beilstein: 7634
• EC Number: 213-344-3
• MDL number: MFCD00005573
• UNSPSC Code: 41106305
• PubChem Substance ID: 24893701
• NACRES: NA.51

Properties

• biological source: synthetic (organic)
• Assay: ≥98%
• form: powder
• mp: 259-262 °C (lit.)
• solubility: water: 50 mg/mL, clear to hazy, colorless to light yellow
• storage temp.: −20°C
• SMILES string: CN(C)c1ncnc2[nH]cnc12
• InChI: 1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)
• InChI key: BVIAOQMSVZHOJM-UHFFFAOYSA-N

Description

General description

6-(Dimethylamino)purine (6-DMAP) is a purine-based metabolite with two condensed heterocyclic rings and two methyl groups linked to the amino group of the purine unit of adenine.

Application

6-(Dimethylamino)purine has been used:

• as a supplement in GR-1 aa medium (bovine medium) for parthenogenetic activation of bovine oocytes to study its potential for embryo development
• in the activation step during the production of nuclear transfer embryos
• as a supplement in HCR2aa medium to activate interspecies embryos derived from interspecies somatic cell nuclear transfer (iSCNT) technique

Biochem/physiol Actions

6-(Dimethylamino)purine (6-DMAP) is a protein kinase and cyclin-dependent kinase inhibitor. It acts as a secondary metabolite and mediates RNA modification. 6-DMAP is a potent cytokinetic inhibitor and is used in parthenogenesis and meiosis studies. It is also used to promote pronuclei formation in mammalian oocytes. 6-DMAP is a dual fluorescence molecule according to femtosecond fluorescence up-conversion spectroscopy studies.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves