This product is soluble in water at 100 mg/ml. The stability of this product in solution form has not been determined. However, the same product with identical CAS number 76939-46-3 is available in the Calbiochem brand portfolio under product number 203800. For this product, the recommended storage conditions in solution form are as follows: after reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C. It is advised to avoid pH levels greater than 8.5. Storage conditions at 4°C or -80°C have not been determined.
B7880
8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt
8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt
≥97% (HPLC), powder
Synonym(s):
8-Br-cAMP
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About This Item
Empirical Formula (Hill Notation):
C10H10BrN5NaO6P
CAS Number:
Molecular Weight:
430.08
Beilstein:
7739743
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Quality Level
Assay
≥97% (HPLC)
form
powder
color
off-white
solubility
H2O: 100 mg/mL
storage temp.
−20°C
SMILES string
[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc12
InChI
1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
InChI key
DMRMZQATXPQOTP-GWTDSMLYSA-M
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General description
8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.
Application
8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:
- to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture[1]
- used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei[2]
- in superfusion medium for head kidneys stimulation[3]
Biochem/physiol Actions
Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.
Cell-permeable cAMP analog with greater resistance to hydrolysis by phosphodiesterases than cAMP.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Other Notes
Membrane-permeable cAMP analog.
Caution
Sensitive to light and moisture.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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What is the storage stability of aliquots [1mM] at 4°C, -20°C and -80°C?
1 answer-
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