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85976

Sigma-Aldrich

Methoxypolyethylene glycol succinate N-hydroxysuccinimide

5,000, ≥90%

Synonym(s):

Polyethylene glycol, mono-Methyl polyethylene glycol succinate N-succinimidyl ester, O-Methyl-O′-succinylpolyethylene glycol 5,000 N-succinimidyl ester, PEG-succinimidyl succinate

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About This Item

CAS Number:
78274-32-5
MDL number:
MFCD00131598
UNSPSC Code:
12162002
PubChem Substance ID:
57653073
NACRES:
NA.25

Assay

≥90%

form

powder

storage temp.

−20°C

InChI

1S/C11H15NO7/c13-5-6-18-7-8(14)1-4-11(17)19-12-9(15)2-3-10(12)16/h13H,1-7H2

InChI key

OVPTZXRXNNJKSJ-UHFFFAOYSA-N

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Application


  • Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation. This study explores the use of Methoxypolyethylene glycol succinate N-hydroxysuccinimide (MPEG-S-NHS) for creating peptide-conjugated polymer micelles that are sensitive to matrix metalloproteinases-2/9. These micelles are designed for site-specific drug release and increased tumor targeting, showcasing a promising application in advanced drug delivery systems (Zhang X, Wang X, Zhong W, Ren X, Sha X, Fang X, 2016) [link].


Linkage

Shearwater Polymers product

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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H Matsuyama et al.
Biological & pharmaceutical bulletin, 16(2), 107-111 (1993-02-01)
Purified sphingomyelinase of Streptomyces A9107 (NRRL 15100) was modified with ss-PEG, methoxypolyethyleneglycol succinimidyl succinate, without loss of activity toward sphingomyelin in the mixed micelles with detergents such as sodium deoxycholate and Triton X-100 or toward a water-soluble, synthetic substrate, HNP
Y P Li et al.
Acta pharmacologica Sinica, 22(6), 549-555 (2001-12-19)
To assess the merits of polyethylene glycol-modified recombinant human tumor necrosis factor alpha (PEG-rHuTNF-alpha). The rHuTNF-alpha was modified with N-succinimidyl succinate monomethoxy polyethylene glycol (SS-PEG) of three different molecular weights. The PEG-rHuTNF-alpha was separated into fractions of various molecular weights
H Matsuyama et al.
Chemical & pharmaceutical bulletin, 39(3), 743-746 (1991-03-01)
Phospholipase D from Streptomyces sp. AA586, PLDP, was modified with methoxypolyethylene glycol succinimidylsuccinate (ss-PEG), an active derivative of polyethylene glycol. By titration with trinitrobenzene sulfonate (TNBS), approximately 70% of the free amino groups in the enzyme protein were shown to
G Sirokmán et al.
Protein science : a publication of the Protein Society, 2(7), 1161-1170 (1993-07-01)
Bacteriorhodopsin (BR), from the purple membrane (PM) of Halobacterium halobium, was chemically modified with methoxypolyethylene glycol (m-PEG; molecular weight = 5,000 Da) succinimidyl carbonate. The polyethylene glycol-bacteriorhodopsin (m-PEG-SC-BR33) conjugate, containing one polyethylene glycol chain, was water soluble. The secondary structure
Georgi As Georgiev et al.
Colloids and surfaces. B, Biointerfaces, 59(2), 184-193 (2007-06-26)
Foam thin liquid films (TLF) and monolayers at the air-water interface formed by DMPC mixed with DMPE-bonded poly (ethylene glycol)s (DMPE-PEG(550), DMPE-PEG(2000) and DMPE-PEG(5000)) were obtained. The influence of both (i) PEG chain size (evaluated in terms of Mw) and
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