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Key Documents

38490

Supelco

5,5-Dimethyl-1,3-cyclohexanedione

for HPLC derivatization, for the determination of aldehyde formaldehyde, ≥99.0%

Synonym(s):

Dimedone, Methone

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About This Item

Linear Formula:
(CH3)2C6H6(=O)2
CAS Number:
Molecular Weight:
140.18
Beilstein:
471489
EC Number:
MDL number:
UNSPSC Code:
12164500
PubChem Substance ID:
NACRES:
NA.21
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grade

for HPLC derivatization

Quality Level

Assay

≥99.0% (GC)
≥99.0%

quality

for the determination of aldehyde formaldehyde

mp

146-148 °C (lit.)

application(s)

general analytical

SMILES string

CC1(C)CC(=O)CC(=O)C1

InChI

1S/C8H12O2/c1-8(2)4-6(9)3-7(10)5-8/h3-5H2,1-2H3

InChI key

BADXJIPKFRBFOT-UHFFFAOYSA-N

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General description

5,5-dimethyl-1,3-cyclohexanedione (Dimedone) is basically a highly sensitive and very specific reagent used for the determination of aldehydes.[1] It is highly advantageous as it is environment friendly, give high yields and is a simple workup procedure.[2]

Application

5,5-dimethyl-1,3-cyclohexanedione may be used in condensation reaction with aromatic aldehyde in ethylene glycol.[3] It may be also be used in trace analysis of aldehydes by HPLC.[1]

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Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Jesse C Patterson et al.
Cell systems, 8(2), 163-167 (2019-02-25)
Although elevated levels of reactive oxygen species (ROS) have been observed in cancer cells and cancer cells aberrantly proliferate, it is not known whether the level of reactive oxygen species and the accumulation of oxidative damage to macromolecules vary across
Trace analysis of aldehydes by reversed-phase high-performance liquid chromatography and precolumn fluorigenic labeling with 5, 5-dimethyl-1, 3-cyclohexanedione.
Kenneth M
Journal of Chromatography A, 256, 243-252 (1983)
Solid-State Condensation Reactions Between Aldehydes and 5, 5-Dimethyl-1, 3-cyclohexanedione by Grinding at Room Temperature.
Tong-shou J
Synthetic Communications, 35 (17), 2339-2345 (2005)
Joseph R Burgoyne et al.
Biochemical Society transactions, 39(5), 1260-1267 (2011-09-23)
Elevated protein oxidation is a widely reported hallmark of most major diseases. Historically, this 'oxidative stress' has been considered causatively detrimental, as the protein oxidation events were interpreted simply as damage. However, recent advances have changed this antiquated view; sensitive
Candice E Paulsen et al.
Chemistry & biology, 16(2), 217-225 (2009-02-24)
Saccharomyces cerevisiae responds to elevated levels of hydrogen peroxide in its environment via a redox relay system comprising the thiol peroxidase Gpx3 and transcription factor Yap1. In this signaling pathway, a central unresolved question is whether cysteine sulfenic acid modification

Questions

  1. May I know the shelf life for 38490 5,5-Dimethyl-1,3-cyclohexanedione?

    1 answer
    1. Retest date is specified at 72 months via product specification, which is for unopened reagent stored in proper conditions. Per our product dating statement, the Retest Period/Retest Date is defined as 'the period of time during which the product is expected to remain within established stability specifications, provided that it has been stored under defined conditions. After the Retest Date, product samples should be examined to ensure that the product is still in compliance with the established specifications.'

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