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535893

Sigma-Aldrich

5-Methyluridine

97%

Synonym(s):

Ribothymidine

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About This Item

Empirical Formula (Hill Notation):
C10H14N2O6
CAS Number:
1463-10-1
Molecular Weight:
258.23
EC Number:
215-973-9
MDL number:
MFCD00006535
UNSPSC Code:
41106305
PubChem Substance ID:
24878114
NACRES:
NA.22

Assay

97%

mp

183-184 °C (lit.)

SMILES string

CC1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(=O)NC1=O

InChI

1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1

InChI key

DWRXFEITVBNRMK-JXOAFFINSA-N

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Marino J E Resendiz et al.
Journal of the American Chemical Society, 134(30), 12478-12481 (2012-07-26)
Photolabile nucleotides that disrupt nucleic acid structure are useful mechanistic probes and can be used as tools for regulating biochemical processes. Previous probes can be limited by the need to incorporate multiple modified nucleotides into oligonucleotides and in kinetic studies
Clive Persaud et al.
Biochemical and biophysical research communications, 392(2), 223-227 (2010-01-14)
Ribosomal RNAs (rRNAs) from all kingdoms contain a variety of post-transcriptional modifications and these are typically clustered in the functional centers of the ribosome. The functions of two bases in the 23S rRNA of Escherichia coli that are post-transcriptionally modified
H An et al.
The Journal of organic chemistry, 66(8), 2789-2801 (2001-04-17)
Novel 5'-O-DMT- and MMT-protected 3'-C-methylene-modified thymidine, 5-methyluridine, and 5-methylcytidine H-phosphonates 1-7 with O-methyl, fluoro, hydrogen, and O-(2-methoxyethyl) substituents at the 2'-position have been synthesized by a new effective strategy from the corresponding key intermediates 3'-C-iodomethyl nucleosides and intermediate BTSP, prepared
S Wang et al.
Biochemistry, 34(12), 4125-4132 (1995-03-28)
Recent studies have shown that there can be large differences in the stability of double and triple helical nucleic acid complexes, depending on whether RNA or DNA strands are involved. These differences have been attributed to structural differences in the
Marcus J O Johansson et al.
RNA (New York, N.Y.), 8(3), 324-335 (2002-05-11)
A 5-methyluridine (m(5)U) residue at position 54 is a conserved feature of bacterial and eukaryotic tRNAs. The methylation of U54 is catalyzed by the tRNA(m5U54)methyltransferase, which in Saccharomyces cerevisiae is encoded by the nonessential TRM2 gene. In this study, we
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