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  • Colonic necrosis in a young patient receiving oral kayexalate in sorbitol: case report and literature review.

Colonic necrosis in a young patient receiving oral kayexalate in sorbitol: case report and literature review.

The Kaohsiung journal of medical sciences (2011-04-06)
Yueh-Hung Chou, Hsin-Yi Wang, Min-Shu Hsieh
ABSTRACT

Kayexalate (sodium polystyrene sulfonate) is a cation-exchange resin used to treat patients with hyperkalemia. Concomitant administration of kayexalate and sorbitol may induce gastrointestinal injury, which is potentially lethal. However, this well-documented complication is often underrecognized both clinically and pathologically. We propose a typical case along with colonoscopic photos and microscopic pictures. Additionally, we also present a review of the literature on this rare drug-induced side effect.

MATERIALS
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Supelco
Sorbitol, Pharmaceutical Secondary Standard; Certified Reference Material
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