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T5651

Sigma-Aldrich

Tetrodotoxin with Citrate Buffer

pH 4.8, powder

Synonym(s):

Fugu poison, Maculotoxin, TTX, Tarichatoxin

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About This Item

Empirical Formula (Hill Notation):
C11H17N3O8
CAS Number:
4368-28-9
Molecular Weight:
319.27
Beilstein:
49176
MDL number:
MFCD00213719
UNSPSC Code:
12352200
PubChem Substance ID:
24900308

form

powder

availability

not available in USA

pH

4.8

solubility

H2O: soluble (stable at pH 4-5 if stored frozen)
strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)

storage temp.

2-8°C

SMILES string

OC[C@@]1(O)[C@H]2OC3(O)OC1C4[C@@H](O)NC(=N)NC4([C@@H]2O)[C@@H]3O

InChI

1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1

InChI key

CFMYXEVWODSLAX-IXUBDLNJSA-N

Gene Information

rat ... Scnn1g(24768)

Application

Tetrodotoxin has been used to study its effects on microglial functions in rats2. This toxin has also been used to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in juvenile zebra finch. This study reported that the toxin causes a decrease in sequence and acoustic variability which result in the production of a stereotyped song by the motor pathway3.

Biochem/physiol Actions

Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Packaging

Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.

Preparation Note

The product is water soluble and stable at pH 4-5 if it is stored frozen. It is unstable in strong acid and alkaline solutions and is rapidly destroyed by boiling at pH 2 and below.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300

Precautionary Statements

P301 + P330 + P331 + P310

Hazard Classifications

Acute Tox. 1 Oral

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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