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α-Bungarotoxin-tetramethylrhodamine

Name: &#945;-Bungarotoxin-tetramethylrhodamine
Brand: SIGMA

from Bungarus multicinctus (Formosan Banded Krait), Nicotinic acetylcholine receptor antagonist

Synonym(s):

TMR-α-BTX

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About This Item

UNSPSC Code:

12352116

NACRES:

NA.77

MDL number:

MFCD00286495

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Properties

Product Name

α-Bungarotoxin-tetramethylrhodamine from Bungarus multicinctus (Formosan Banded Krait),

mol wt

~8,500

Quality Segment

100

color

red

solubility

H₂O: soluble

storage temp.

−20°C

Description

Application

α-Bungarotoxin-tetramethylrhodamine from Bungarus multicinctus was used at a dilution of 1:220 to identify the distribution of nicotinic acetylcholine receptors at neuromuscular junctions of longitudinal sections of rat gastrocnemius muscle.[1]

α-Bungarotoxin-tetramethylrhodamine from Bungarus multicinctus (Formosan Banded Krait) has been used in immunofluorescence staining (1:200) for identification of neuromuscular junction in experimental models.[2][3] It has also been used to block muscle contraction in myotome cells.[4]

Biochem/physiol Actions

α-Bungarotoxin is a high-affinity antagonist for nicotinic acetylcholine receptors (AChRs) from muscle but not the neurons. Labeling α-Bungarotoxin with tetramethylrhodamine enables the detection of bungarotoxin-binding receptors at neuromuscular junctions.[5][6]

Useful for detecting the distribution of nicotinic acetylcholine receptors at neuromuscular junctions.

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This Item	203980	203732	P8887
Sigma-Aldrich T0195 α-Bungarotoxin-tetramethylrhodamine from Bungarus multicinctus (Formosan Banded Krait)	Sigma-Aldrich 203980 α-Bungarotoxin, Bungarus multicinctus	Sigma-Aldrich 203732 Brevetoxin PbTx-2, Ptychodiscus brevis	Sigma-Aldrich P8887 5α-Pregnan-3α-ol-20-one
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
mol wt ~8,500	mol wt -	mol wt -	mol wt -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. -
solubility H₂O: soluble	solubility PBS: soluble, water: soluble	solubility ethyl acetate: soluble, methanol: soluble, water: soluble	solubility DMSO: 5 mg/mL, methanol: soluble
color red	color -	color tan to white	color white

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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