SRP4137
IL-4 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
B cell stimulating factor, BCDF, BCGF, BSF-1, IL-4, Lymphocyte stimulatory factor 1
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General description
The gene IL-4 (interleukin 4) is mapped to human chromosome 5q31.1. Human IL-4 is a 15kDa globular protein containing 130 amino acid residues. It is a cytokine which is mainly secreted by activated Th2 (T helper) cells.
Application
IL-4 (interleukin 4) has been used to polarize the human monocytic leukemia (THP-1) cells to M2-like phenotype.
In inflamed porcine endometrium, IL-4 (interleukin 4)-human has been used to study effects of IL-4 on the leukotriene B4 and leukotriene C4 synthesis as well as secretion. It has been used to study the effect of IL-4 on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs.
Biochem/physiol Actions
IL-4 (Interleukin 4) is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It exhibits anti-inflammatory responses and participates in immune processes by providing protection from intracellular pathogens. IL-4 also plays an important role in Th2 (T helper cells) differentiation. Additionally, it can suppress pro-inflammatory cytokines. IL-4 is associated with pemphigus. Also, mutation in the gene is linked with risk of dental implant loss. In children, IL-4 might be involved with risk of asthma and Mycoplasma pneumoniae infection.
Physical form
Sterile filtered and lyophilized with no additives.
Reconstitution
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Association of interleukin 4 gene polymorphisms with dental implant loss.
Pigossi SC, et al.
Implant Dentistry, 23, 723-731 (2014)
Purification of a 130-kDa T cell glycoprotein that binds human interleukin 4 with high affinity.
Galizzi JP, et al.
The Journal of Biological Chemistry, 265, 439-444 (1990)
Shuichi Sakamoto et al.
Oncoimmunology, 8(12), e1671760-e1671760 (2019-11-20)
A solid tumor consists of cancer and stromal cells, which comprise the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) are usually abundant in the TME, contributing to tumor progression. In cases of peritoneal dissemination of gastric cancer (GC), the contribution of
Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations.
Marsh DG, et al.
Science, 264, 1152-1156 (1994)
Effect of lipopolysaccharide and cytokines on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs.
Jana B and Czarzasta J
Animal Reproduction Science, 168, 116-125 (2016)
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