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SRE0016

Sigma-Aldrich

MATP+

substrate for analysis of acetylcholinesterase (AChE) activity

Synonym(s):

1,1-dimethyl-4-acetylthiomethylpiperidinium iodide, acetylcholinesterase substrate, MATP+

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About This Item

Empirical Formula (Hill Notation):
C10H20INOS
Molecular Weight:
329.24
UNSPSC Code:
12352204
PubChem Substance ID:
329826113
NACRES:
NA.83

product name

MATP+,

storage temp.

2-8°C

Quality Level

200

SMILES string

CC(SCC1CC[N+](C)(C)CC1)=O.[I-]

InChI

1S/C10H20NOS.HI/c1-9(12)13-8-10-4-6-11(2,3)7-5-10;/h10H,4-8H2,1-3H3;1H/q+1;/p-1

InChI key

WLNVGCIMLLIQAL-UHFFFAOYSA-M

General description

1,1-Dimethyl-4-acetylthiomethylpiperidinium iodide (MATP+) is a substrate for analysis of acetylcholinesterase (AChE) activity.  MATP+ is highly selective for specific detection of AChE activity, and thus is advantageous over other AChE substrates like acetylcholine, which can react with multiple enzymes like AChE and also butylcholinesterase (BChE).  Thus with MATP+ in the AChE assay, there is no need to include BChE inhibitors in the protocol.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hachiro Sugimoto
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 124(3), 163-170 (2004-08-31)
Enhancement of the activity of cholinergic neurons has been regarded as one of the most promising methods for treating Alzheimer's disease (AD). Donepezil is a representative acetylcholinesterase inhibitor (AChEI) and is a great success among the AChEI drugs. AChEIs are
Nobuo Tsuruoka et al.
PloS one, 7(11), e50824-e50824 (2012-12-05)
Diketopiperazines (DKPs) are naturally-occurring cyclic dipeptides with a small structure and are found in many organisms and in large amounts in some foods and beverages. We found that a chicken essence beverage, which is popular among Southeast Asians as a
Tatsuya Kikuchi et al.
Biological & pharmaceutical bulletin, 33(4), 702-706 (2010-04-23)
The activity of acetylcholinesterase (AChE) is measured to obtain pathological information about the cholinergic system in various disease states and to assess the effect of AChE inhibitors. Using Ellman's method that is commonly used in such examinations, butyrylcholinesterase inhibitors must

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