SML1801
CeMMEC13
≥98% (HPLC)
Synonym(s):
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,2-dihydro-1-methyl-2-oxo-4-quinolinecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C19H16N2O4
CAS Number:
Molecular Weight:
336.34
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
CN(C1=C2C=CC=C1)C(C=C2C(NC3=CC=C4C(OCCO4)=C3)=O)=O
Biochem/physiol Actions
CeMMEC13 is a potent inhibitor of the second bromodomain of the transcription initiation factor TAF1 with an an IC50 value of 2.1 μM and with minimal inhibition of BRD4, BRD9, CREBBP, or EP300. CeMMEC13 was found to synergize with BRD4 inhibitor (S)-JQ1 to arrest the proliferation of leukemia cell line THP1 and lung adenocarcinoma cell line H23.
CeMMEC13 is a potent inhibitor of the second bromodomain of the transcription initiation factor TAF1.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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