SAB1407126

Anti-USP18 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• Synonym(s): ISG43, UBP43
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~43 kDa
• species reactivity: human
• technique(s): indirect immunofluorescence: suitable; western blot: 1 μg/mL
• NCBI accession no.: NM_017414.2
• UniProt accession no.: Q9UMW8
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... USP18(11274)

Description

General description

Ubiquitin-specific peptidase 18 (USP18), an isopeptidase codes for a protein with a molecular mass of 43 KDa, UBP43. The promoter region of USP18 gene possesses interferon-sensitive response elements (ISREs). USP18 protein has cysteine and histidine boxes, that are responsible for enzymatic activity. The expression of USP18 is seen in the liver, thymus, and spleen. It is also expressed at a low level in adipose tissue, lung, and bone marrow. The USP18 gene is located on human chromosome 22q11.2.

Immunogen

USP18 (NP_059110.2, 1 a.a. ~ 372 a.a) full-length human protein.

Sequence
MSKAFGLLRQICQSILAESSQSPADLEEKKEEDSNMKREQPRERPRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYLKLWNLIKDQITDVHLVERLQALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPNYHWQETAYLLVYMKMEC

Biochem/physiol Actions

Ubiquitin-specific peptidase 18 (USP18) serves as a modulator of interferon type 1 (IFN-I) signaling. It plays a major role in stress responses and signal transduction pathways. This protein is also involved in responses to the infection of virus and bacteria. Through interferon stimulated gene 15 (ISG15) (ISGylation), it can reverse the post-translational modifications (PTM) of target proteins.

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable