PZ0323

PF-06767832

≥98% (HPLC)

• Synonym(s): 1,5-Anhydro-2,3-dideoxy-3-[[[5-methyl-4-[[4-(4-thiazolyl)phenyl]methyl]-2-pyridinyl]carbonyl]amino]-L-threo-pentitol, N-((3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl)-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide, PF 6767832
• Empirical Formula (Hill Notation): C₂₂H₂₃N₃O₃S
• CAS Number: 1859081-58-5
• Molecular Weight: 409.50
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823840
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 30 mg/mL, clear
• storage temp.: room temp
• SMILES string: CC1=CN=C(C(N[C@@H]2[C@@H](O)COCC2)=O)C=C1CC3=CC=C(C4=CSC=N4)C=C3
• InChI: 1S/C22H23N3O3S/c1-14-10-23-19(22(27)25-18-6-7-28-11-21(18)26)9-17(14)8-15-2-4-16(5-3-15)20-12-29-13-24-20/h2-5,9-10,12-13,18,21,26H,6-8,11H2,1H3,(H,25,27)/t18-,21-/m0/s1
• InChI key: VVZZHFMLRHJXTO-RXVVDRJESA-N

Description

Biochem/physiol Actions

PF-06767832 is a cell permeable, potent and selective M1 muscarinic acetylcholine receptor Positive Allosteric Modulator (PAM). Studies have shown that PF-06767832 potentiates the activity of acetylcholine (Ach) in vitro.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable