PLA0029

Rabbit anti-BLM Antibody, Affinity Purified

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• Synonym(s): BS, Bloom syndrome, DNA helicase, RECQ2, RECQL2, RECQL3, RecQ helicase-like, RecQ-like type 2, recQ protein-like 3
• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IP, WB
• Citations: 2

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: human, mouse
• technique(s): immunoprecipitation (IP): 2-10 μg/mg, western blot: 1:1,000- 1:10,000
• accession no.: NP_000048.1
• UniProt accession no.: P54132
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: rabbit ... BLM(641)

Description

Immunogen

The epitope recognized by PLA0029 maps to a region between residue 1325 and the C-terminus (residue 1417) of human Bloom Syndrome using the numbering given in entry NP_000048.1 (GeneID 641).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

Bloom syndrome protein (BLM) is a RecQ DNA-helicase that plays a role in DNA replication and repair. Mutations and inactivation of BLM result in human syndromes characterized by dwarfism, infertility, erythema, learning disabilities, immune deficiency and predisposition to cancer. BLM has been shown to associate with the BRCA1-associated genome surveillance complex (BASC) which contains BRCA1, MSH2, MSH6, MLH1, ATM, PMS2 and the RAD50-MRE11-NBS1 protein complex.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable