The surface charge and empirical formula of this product hve not been determined. Please see the link below to review a publication that may be of interest:
https://pmc.ncbi.nlm.nih.gov/articles/PMC323473/
P3235
Prostate Specific Antigen from human semen
buffered aqueous solution
Synonym(s):
Cancer-associated PSA, PSA
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About This Item
Form:
buffered aqueous solution
Assay:
≥99% (SDS-GE)
Biological source:
human semen
Pricing and availability is not currently available.
General description
Prostate specific antigen (PSA) is a 26kDa single-chain glycoprotein containing 237 amino acids, encoded by the kallikrein gene mapped to human chromosome 19. It is specifically expressed by human prostate tissue and is a highly abundant proteolytic enzyme expressed in the seminal fluid.[1]
Biochem/physiol Actions
Prostate-specific antigen (PSA) is an androgen-regulated serine protease specifically produced by prostatic tissue and is secreted into the lumen. PSA in semen cleaves semenogelins present in the seminal coagulum. Total PSA levels are increased in serum of prostate cancer (PCa) patients. PSA functions as a potential biomarker for PCa.[2][1] Serum protease inhibitors such as α1-antichymotrypsin (α1-ACT), α2-macroglobulin (α2-M) and other acute-phase proteins form irreversible complexes with circulating PSA and hinder proteolytic activity of PSA.
Glycoprotein of the glandular kallikrein family
Prostate Specific Antigen (PSA), a glycoprotein of the glandular kallikrein family, is a serine protease with chymotrypsin-like enzymatic activity. Circulating PSA exists in free and protease inhibitor-bound forms. Studying the ratios of free to inhibitor-bound forms may prove valuable in the diagnosis of prostate cancer.
Physical form
Solution in 10 mM Tris, 0.1% sodium azide, pH 8.0
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This Item | |||
|---|---|---|---|
| biological source human semen | biological source human semen | biological source human | biological source human |
| assay ≥99% (SDS-GE) | assay ≥95% (SDS-GE) | assay ≥95% (SDS-PAGE) | assay ≥99% (SDS-PAGE) |
| form buffered aqueous solution | form buffered aqueous solution | form lyophilized | form buffered aqueous solution |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. −70°C | storage temp. −20°C |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. |
| shipped in wet ice | shipped in - | shipped in dry ice | shipped in wet ice |
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hello, I would like to get some information about PSA Antigen from human semen. What is the surface charge and could you send the Empirical Formula.
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