P3136
Polydeoxyguanylic acid · Polydeoxycytidylic acid sodium salt
double-stranded homopolymer
Synonym(s):
Poly(dG) • Poly(dC)
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
form
solid
storage temp.
−20°C
Application
Polydeoxyguanylic acid • Polydeoxycytidylic acid (Poly(dG) • Poly(dC)) is a high molecular weight double-stranded homopolymer DNA model compound used for conformational studies of DNA structure dynamics and drug and small molecule interactions.
Other Notes
High molecular weight double-stranded homopolymer
Unit Definition
One unit will yield an A260 of 1.0 in 1.0 ml of 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1 cm light path).
Reconstitution
Polymers composed of dG and dC can be difficult to dissolve. The recommended dissolution method for poly(dG) • poly(dC) is to suspend the polymer in a minimum of 15 μl per unit in water or buffer and heat to 50-55 °C for 30 minutes with occasional mixing by inversion.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Sebastiano Campagna et al.
Inorganic chemistry, 50(21), 10667-10672 (2011-10-01)
Efficient intercalation of a luminescent Ir(III) complex exclusively made of polypyridine ligands in natural and synthetic biopolymers is reported for the first time. The emission of the complex is largely enhanced in the presence of [poly(dA-dT)(2)] and strongly quenched in
Studies of the fluorescence light-up effect of amino-substituted benzo[b]quinolizinium derivatives in the presence of biomacromolecules.
Faulhaber K, Granzhan A, Ihmels H, et al.
Photochemistry and Photobiology, 10, 1535-1545 (2011)
M Behe et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(3), 1619-1623 (1981-03-01)
We have compared the behavior in solution of the synthetic polynucleotide poly(dG-m5dC).poly(dG-m5dC) with that of the unmethylated polynucleotide poly(dG-dC).poly(dG-dC). In solutions containing high concentrations of salt, poly(dG-dC).poly(dG-dC) is known to exhibit altered circular dichroic and absorption spectra correlated with formation
Marta Airoldi et al.
Journal of biomolecular structure & dynamics, 23(4), 465-478 (2005-12-21)
The model polynucleotide poly(dG-dC).poly(dG-dC) (polyGC) was titrated with a strong acid (HCl) in aqueous unbuffered solutions and in the quaternary w/o microemulsion CTAB/n-pentanol/n-hexane/water. The titrations, performed at several concentrations of NaCl in the range 0.005 to 0.600 M, were followed
Effect of the alkaline cations on the stability of the model polynucleotide poly(dG-dC)·poly(dG-dC).
Marta Airoldi et al.
Journal of biomolecular structure & dynamics, 29(3), 585-594 (2011-11-10)
When the model polynucleotide poly(dG-dC)∙poly(dG-dC) [polyGC] is titrated with a strong acid (HCl) in unbuffered aqueous solutions containing the chlorides of the alkali metals in the concentration range 0.010 M-0.600 M, two transitions in the absorbance vs. pH plots are evidenced, characterized
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service