G8634

Guanosine 5′-[γ-thio]triphosphate tetralithium salt

Name: Guanosine 5&#8242;-[&#947;-thio]triphosphate tetralithium salt
Brand: SIGMA

≥90% (contains < 10% GDP, HPLC), G-protein activator, powder

Synonym(s):

GTPγS tetralithium salt, GTP-γ-S-Li₄, Guanosine 5′-O-(3-thiotriphosphate) tetralithium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₂Li₄N₅O₁₃P₃S

CAS Number:

94825-44-2

Molecular Weight:

562.98

NACRES:

NA.77

PubChem Substance ID:

24895344

UNSPSC Code:

41106305

EC Number:

305-606-1

MDL number:

MFCD00135151

Beilstein/REAXYS Number:

8182249

Assay:

≥90% (contains < 10% GDP, HPLC)

Form:

powder

Key Documents

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Product Name

Guanosine 5′-[γ-thio]triphosphate tetralithium salt, ≥90% (contains < 10% GDP, HPLC), powder

assay

≥90% (contains < 10% GDP, HPLC)

form

powder

color

white to off-white

solubility

H₂O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Li+].[Li+].[Li+].[Li+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O13P3S.4Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-29(19,20)27-30(21,22)28-31(23,24)32;;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H,21,22)(H2,23,24,32)(H3,11,13,14,18);;;;/q;4*+1/p-4/t3-,5-,6-,9-;;;;/m1..../s1

InChI key

AMQXJFWJOAWCPV-ZVQJTLEUSA-J

Related Categories

Bioactive Small Molecules

Phosphates

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1 of 4

This Item	G5884	A8016	M3509
G8634 Guanosine 5′-[γ-thio]triphosphate tetralithium salt	Sigma-Aldrich G5884 Guanosine 5′-triphosphate lithium salt	Sigma-Aldrich A8016 Adenosine 5′-[β-thio]diphosphate trilithium salt	Sigma-Aldrich M3509 β,γ-Methyleneguanosine 5′-triphosphate sodium salt
form powder	form powder	form powder	form powder
assay ≥90% (contains < 10% GDP, HPLC)	assay ~95% (HPLC)	assay ≥80% (HPLC)	assay ≥98% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: ≥75 mg/mL (Solutions are very unstable; prepare immediately prior to use.)	solubility H₂O: 100 mg/mL	solubility -	solubility water: 50 mg/mL, clear, colorless
shipped in dry ice	shipped in dry ice	shipped in -	shipped in -

Application

Guanosine 5′-[γ-thio]triphosphate tetralithium salt has been used:

as a component of lysis buffer
in oocyte and mammalian cell patch-clamp experiments to keep the G proteins in a constantly active state[1]
to couple with G- protein α, to study its effect on kinase activity

Biochem/physiol Actions

GTP-γ-S is a non-hydrolyzable GTP analog, known for its role as a G-protein activator. It has recently been shown to protect proteins from proteolytic degradation, stimulate GLUT4 translocation in a tyrosine kinase-dependent manner, stimulate phospholipases and induce actin polymerization in vitro.

Non-hydrolyzable GTP analog, a G-protein activator.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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(1,3)-β-d-Glucan synthase (GS) is an essential enzyme for fungal cell wall biosynthesis that catalyzes the synthesis of (1,3)-β-d-glucan, a major and vital component of the cell wall. GS is a proven target of antifungal antibiotics including FDA-approved echinocandin derivatives; however

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Global Trade Item Number

SKU	GTIN
G8634-1MG	04061833649688
G8634-10MG	04061833645420
G8634-25MG	04061833649695
G8634-5MG	04061833649701

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