G8279
Gum guaiac
crude colorimetric peroxidase substrate
Synonym(s):
Guaiac, Guaiacum, Resin guaiac
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About This Item
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form
powder
mp
85 °C (dec.) (lit.)
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Application
Gum guaiac is a tree resin and crude source of 2,5-di-(4-hydroxy-3-methoxyphenyl)-3,4-dimethylfuran (α-guaiaconic acid). The phenolic α-guaiaconic acid acts as a colorimetric peroxidase substrate. When reacted with an organic or inorganic oxidizing agent, the α-guaiaconic acid is oxidized to a blue-colored quinone. The guaiac reaction has been used to detect trace amounts of heme from hemoglobin in the presence of peroxide.
The Nobles test can be performed using 67% (w/v) gum guaiac diluted in 96% ethanol to analyze the level of extracellular oxidase production
Other Notes
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Mechanism of Oxidation in the Plant. Part II: An Investigation of Substances which are capable of behaving as Peroxydases.
P H Gallagher
The Biochemical journal, 18(1), 29-38 (1924-01-01)
C K Palmer et al.
British journal of cancer, 110(7), 1705-1711 (2014-03-13)
Screening for bowel cancer using the guaiac faecal occult blood test offered by the NHS Bowel Cancer Screening Programme (BCSP) is taken up by 54% of the eligible population. Uptake ranges from 35% in the most to 61% in the
S Webendörfer et al.
Deutsche medizinische Wochenschrift (1946), 139(3), 79-83 (2013-10-04)
If the diagnosis is made early the cure rate of bowel cancer is more than 90 %. Occupational preventative medical care required by law and carried out by company physicians can be supplemented by a medical consultation and by simple screenings
Isolation and characterization of α-guaiaconic acid and the nature of guaiacum blue.
Kratochvil, J.F., et al.
Phytochemistry, 10, 2529-2531 (1971)
The Properties and Classification of the Oxidizing Enzymes, and Analogies between Enzymic Activity and the Effects of Immune Bodies and Complements.
E Whitley
The Biochemical journal, 4(3-4), 136-167 (1909-01-01)
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