G5640
Globulins Cohn fraction II, III from goat
Synonym(s):
Vitamin D binding protein
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About This Item
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biological source
goat
Assay
73-90% protein basis (biuret)
form
lyophilized powder
composition
Protein, 73-90% biuret
solubility
H2O: soluble 25 mg/mL
storage temp.
2-8°C
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General description
Vitamin D binding protein (DBP) is a polymorphic protein that specifically binds to vitamin D and its metabolites. This protein belongs to the albuminoid family and is highly conserved among vertebrates. The gene encoding DBP is mapped to human chromosome 4q11-q13. It is predominantly produced in the liver and is also expressed in the kidney, endocrine pancreatic cells, fat cells, and testis.
Application
Globulins were used in Biotin/avidin formulations.
Biochem/physiol Actions
Vitamin D binding protein (DBP) specifically binds and transports vitamin D and its metabolites with high affinity. It promotes fibrillar actin clearance by binding to actin monomers. DBP also binds to unsaturated fatty acids, megalin-cubilin receptor complex, the membrane of leukocytes, and the activation of the complement C5 system. The levels of DBP indicate the free concentration of all vitamin D metabolites. Decreased levels of serum DBP are observed in liver diseases, nephrotic syndrome, malnutrition, severe acute trauma, or disease.
Other Notes
Primarily γ-globulins
Physical form
Lyophilized powder containing NaCl
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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