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D0670

Sigma-Aldrich

Dihydroouabain

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About This Item

Empirical Formula (Hill Notation):
C29H46O12
CAS Number:
1183-35-3
Molecular Weight:
586.67
EC Number:
214-663-0
MDL number:
MFCD00049227
UNSPSC Code:
12352200
PubChem Substance ID:
24278355

SMILES string

[H][C@@]12CC[C@]3(O)C[C@H](C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]4(C)[C@H](CC[C@]24O)[C@H]5COC(=O)C5)O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O

InChI

1S/C29H46O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h13-19,21-25,30-32,34-38H,3-12H2,1-2H3/t13-,14?,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1

InChI key

ZTFGOPUOTATSAL-CFVDWFIMSA-N

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Biochem/physiol Actions

Cardiac glycoside; an inhibitor of the sodium-potassium pump.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 + H331

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Cyrille Vaillend et al.
Journal of neurophysiology, 88(6), 2963-2978 (2002-12-06)
Extra- and intracellular records were made from rat acute hippocampal slices to examine the effects of partial inhibition of Na(+)-K(+)-ATPases (Na(+)-K(+) pumps) on neuronal hyperexcitability. Bath application of the low-affinity cardiac glycoside, dihydroouabain (DHO), reversibly induced interictal-like epileptiform bursting activity
K Quinn et al.
American journal of physiology. Heart and circulatory physiology, 279(1), H351-H360 (2000-07-19)
Electrogenicity of the Na(+)/K(+) pump has the capability to generate a large negative membrane potential independently of ion-channel current. The high background membrane resistance of arterioles may make them susceptible to such an effect. Pump current was detected by patch-clamp
Rossana Scuri et al.
The European journal of neuroscience, 25(1), 159-167 (2007-01-24)
Increasing evidence indicates that modulation of Na(+)/K(+) ATPase activity is involved in forms of neuronal and synaptic plasticity. In tactile (T) neurons of the leech Hirudo medicinalis, Na(+)/K(+) ATPase is the main determinant of the afterhyperpolarization (AHP), which characterizes the
Raimondo D'Ambrosio et al.
Journal of neurophysiology, 87(1), 87-102 (2002-01-11)
Little information is available on the specific roles of different cellular mechanisms involved in extracellular K(+) homeostasis during neuronal activity in situ. These studies have been hampered by the lack of an adequate experimental paradigm able to separate K(+)-buffering activity
Isamu Ito et al.
Investigative ophthalmology & visual science, 47(2), 683-692 (2006-01-25)
To evaluate the effect of acute exposure to high glucose on myogenic tone and reactivity of the rat ophthalmic artery and to compare the observations with that in ophthalmic artery from a diabetic rat model. Ophthalmic arteries from Sprague-Dawley rats
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