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BW B70C

Name: BW B70C
Brand: SIGMA

>98% (HPLC), solid

Synonym(s):

N-[3-[3-4(-Fluorophenoxy)phenyl]-1-methyl-2-propenyl]-N-hydroxyurea

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₇FN₂O₃

CAS Number:

134470-38-5

Molecular Weight:

316.33

NACRES:

NA.77

PubChem Substance ID:

24278269

UNSPSC Code:

51111800

MDL number:

MFCD00890868

Assay:

>98% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

>98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble 22 mg/mL

storage temp.

2-8°C

SMILES string

CC(\C=C\c1cccc(Oc2ccc(F)cc2)c1)N(O)C(N)=O

InChI

1S/C17H17FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-12,22H,1H3,(H2,19,21)/b6-5+

InChI key

UAIYNMRLUHHRMF-AATRIKPKSA-N

Gene Information

human ... ALOX5AP(241)

Description

Application

BW B70C has been used as a 5-lipoxygenase inhibitor to study its effects on eryptosis in erythrocytes.[1]

Biochem/physiol Actions

Selective 5-lipoxygenase inhibitor.

BW B70C exhibits anti-inflammatory and anti-tumorigenic activities.[2] It exhibits therapeutic effects against hepatocellular carcinoma.[3] BW B70C plays a role in allergen-induced bronchoconstriction by reducing the allergic airway closure and glycoconjugate secretion.[4]

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This Item	SML0143	S5192	C9867
Sigma-Aldrich B4558 BW B70C	Sigma-Aldrich SML0143 HC-067047	Sigma-Aldrich S5192 SB 222200	Sigma-Aldrich C9867 CGK733
assay >98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form powder	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: soluble 22 mg/mL	solubility DMSO: ≥15 mg/mL	solubility DMSO: soluble ~28 mg/mL, H₂O: insoluble	solubility DMSO: >5 mg/mL
color white	color white to tan	color light yellow	color off-white

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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