B2805

BMP6, human

Name: BMP6, human
Brand: SIGMA

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonym(s):

Bone Morphogenetic Protein 6 human, BMP-6

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD02097809

Biological source:

human

Recombinant:

expressed in NSO cells

Assay:

>95% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

30–38 kDa

Impurities:

endotoxin, tested

Key Documents

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Product Name

Bone Morphogenetic Protein 6 human, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

biological source

human

recombinant

expressed in NSO cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

0.05-0.15 μg/mL ED₅₀

mol wt

30–38 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P22004

storage temp.

−20°C

Quality Level

100

Gene Information

human ... BMP6(654)

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Show Differences

1 of 4

This Item	B1814	H4916	H4791
Sigma-Aldrich B2805 Bone Morphogenetic Protein 6 human	Sigma-Aldrich B1814 Bone Morphogenetic Protein 2 human	Sigma-Aldrich H4916 Bone Morphogenetic Protein 4 human	Sigma-Aldrich H4791 Bone Morphogenetic Protein 2 human
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
recombinant expressed in NSO cells	recombinant expressed in E. coli	recombinant expressed in HEK 293 cells	recombinant expressed in HEK 293 cells
assay >95% (SDS-PAGE)	assay ≥98% (SDS-PAGE)	assay >95% (SDS-PAGE)	assay -
biological source human	biological source human	biological source human	biological source human
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

Biochem/physiol Actions

Cellular responses to BMP-6 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Mature human and murine BMP-6 demonstrates 96% homology.

Physical form

Lyophilized from 200 ul 0.2 μm filtered solution in 40% acetonitrile, 0.1% trifluoroacetic acid containing 50ug bovine serum albumin per 1 ug as a carrier protein.

Analysis Note

The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Bone morphogenetic proteins and their receptors: potential functions in the brain.

Ebendal, T., et al

The Journal of Neuroscience, 51, 139-146 (1998)

Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease.

Stephanie Arndt et al.

Gut, 64(6), 973-981 (2014-07-12)

Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis. However, its further role in liver pathology including non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH) is elusive. The aim of this

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.

Christine E McLaren et al.

Hepatology (Baltimore, Md.), 62(2), 429-439 (2015-01-22)

To identify polymorphisms associated with variability of iron overload severity in HFE-associated hemochromatosis, we performed exome sequencing of DNA from 35 male HFE C282Y homozygotes with either markedly increased iron stores (n = 22; cases) or with normal or mildly increased iron

A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression.

Hiroshi Kawabata et al.

Experimental hematology, 43(5), 404-413 (2015-01-31)

Hepcidin is the central regulator of systemic iron homeostasis; dysregulation of hepcidin expression causes various iron metabolic disorders, including hereditary hemochromatosis and anemia of inflammation. To identify molecules that modulate hepcidin expression, we developed a bioassay system for hepcidin gene

The research on the immuno-modulatory defect of mesenchymal stem cell from Chronic Myeloid Leukemia patients.

Zhu Xishan et al.

Journal of experimental & clinical cancer research : CR, 30, 47-47 (2011-05-04)

Overwhelming evidence from leukemia research has shown that the clonal population of neoplastic cells exhibits marked heterogeneity with respect to proliferation and differentiation. There are rare stem cells within the leukemic population that possess extensive proliferation and self-renewal capacity not

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