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32122

Supelco

5′-Hydroxypiroxicam

VETRANAL®, analytical standard

Synonym(s):

4-Hydroxy-N-(5-hydroxy-2-pyridyl)-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C15H13N3O5S
CAS Number:
77459-78-0
Molecular Weight:
347.35
Beilstein:
5142716
MDL number:
MFCD23136990
UNSPSC Code:
41116107
PubChem Substance ID:
329754054
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CN1C(C(=O)Nc2ccc(O)cn2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C15H13N3O5S/c1-18-13(15(21)17-12-7-6-9(19)8-16-12)14(20)10-4-2-3-5-11(10)24(18,22)23/h2-8,19-20H,1H3,(H,16,17,21)

InChI key

CCKOORANQAQKKV-UHFFFAOYSA-N

General description

5′-Hydroxypiroxicam (CAS:77459-78-0) belongs to the VETRANAL product line of high purity veterinary drug standards used for the determination of the active ingredients of the drug in processed food of animal origin.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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A Klopas et al.
Journal of pharmaceutical and biomedical analysis, 17(3), 515-524 (1998-07-10)
A zero-crossing first-derivative spectrophotometric method for the determination of piroxicam and its major metabolite 5-hydroxypiroxicam (5-HP) in human plasma is described. This technique permits the quantification of compounds with closely overlapping spectral bands without any separation step. The method consists
V Ródenas et al.
The Analyst, 123(8), 1749-1752 (1999-03-11)
A first-derivative spectrophotometric method for the simultaneous determination of piroxicam (PX) and its major metabolite 5'-hydroxypiroxicam (OH PX) in human plasma is described. The method consists of direct extraction of the two drugs from the plasma samples with hydrochloric and
High-performance liquid chromatographic analysis of piroxicam and its major metabolite 5'-hydroxypiroxicam in human plasma and urine.
C J Richardson et al.
Journal of chromatography, 382, 382-388 (1986-10-31)
P A Milligan
Journal of chromatography, 576(1), 121-128 (1992-04-15)
A simple and sensitive liquid chromatographic method with ultraviolet detection is described for the determination of the nonsteroidal anti-inflammatory drug piroxicam and its major metabolites in human plasma, urine and bile. Separation of these components occurs on a reversed phase
B A Mueller et al.
Pharmacotherapy, 12(2), 93-97 (1992-01-01)
We compared the endoscopic effects and pharmacokinetic profiles of an experimental buccal formulation of piroxicam to oral capsules in an attempt to determine whether nonsteroidal antiinflammatory drug-induced gastropathy is due to a local or systemic effect. Ten healthy subjects received
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