554994

RHC-80267

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells.

• Synonym(s): RHC-80267, 1,6- bis(Cyclohexyloximinocarbonylamino)hexane
• Empirical Formula (Hill Notation): C₂₀H₃₄N₄O₄
• CAS Number: 83654-05-1
• Molecular Weight: 394.51
• MDL number: MFCD00210844
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to off-white
• solubility: DMSO: 25 mg/mL; ethanol: 25 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
• InChI key: RXSVYGIGWRDVQC-UHFFFAOYSA-N

Description

General description

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Biochem/physiol Actions

Cell permeable: no

Primary Target
DAG lipase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4 nM against DAG lipase activity in canine platelets

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295.
Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207.
Konrad, R.J., et al. 1994. Biochemistry 33, 13284.
Mason-Garcia, M., et al. 1992. Am. J. Physiol.262, C1197.
Balsinde, J., et al. 1991. J. Biol. Chem.266, 15638.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable