5.00511
Histone Acetyltransferase Inhibitor VIII, NU9056
Synonym(s):
Histone Acetyltransferase Inhibitor VIII, NU9056, HAT Inhibitor VIII, p300/CBP Inhibitor VII, PCAF Inhibitor V, 1,2-Bis(isothiazol-5-yl)disulfane, 1,2-di(isothiazol-5-yl)disulfane, KAT5 Inhibitor I, Tip60 Inhibitor I
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About This Item
Empirical Formula (Hill Notation):
C6H4N2S4
CAS Number:
Molecular Weight:
232.37
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
oil
Storage condition:
OK to freeze, protect from light
assay
≥97% (HPLC)
Quality Segment
form
oil
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow-brown
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
SMILES string
[s]1nccc1SSc2[s]ncc2
InChI
1S/C6H4N2S4/c1-3-7-9-5(1)11-12-6-2-4-8-10-6/h1-4H
InChI key
MLRAMCAHIWHWRM-UHFFFAOYSA-N
General description
NU9056, a disulfane compound, is reported to be a potent inhibitor of lysine acetyltransferase 5 (KAT5). NU9056 inhibits protein acetylation in prostate cancer cell lines. It acts against histone acetyltransferase KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC50 ≤2, ≤36, ≤60, and >100 µM, respectively) and effectively reduces H3K14, H4K8, H4K16, but not α-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10 µM). Shown to induce cell cycle arrest and apoptosis (17 to 24 µM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI50 from 7.5 to 27 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
KAT5
KAT5
Reversible: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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