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1.04352

L-Histidine

EMPROVE® EXPERT, Ph. Eur., ChP, JP, USP

Synonym(s):

His, (S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773

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About This Item

Empirical Formula (Hill Notation):
C6H9N3O2
CAS Number:
Molecular Weight:
155.15
EC Index Number:
200-745-3
UNSPSC Code:
12352209
Beilstein/REAXYS Number:
84088
MDL number:
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Quality Segment

agency

ChP, JP, Ph. Eur., USP

product line

EMPROVE® EXPERT

form

solid

technique(s)

API processing | cocrystal formation: suitable

pH

7.7 (20 °C, 10 g/L in H2O)

mp

282 °C (dec.) (lit.)

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

2-30°C

SMILES string

N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Histidine is used in biopharma manufacturing as a buffer in formulation. It is often used together with histidine monohydrochloride to prepare histidine buffer with the desired pH value.
Due to its low microbial and endotoxin limits, L-Histidine Emprove® Expert is especially suitable for high-risk applications.

Biochem/physiol Actions

Precursor of histamine by action of histidine decarboxylase.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item
130850573767H6034
application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

advanced drug delivery
peptide synthesis
pharmaceutical (small molecule)

technique(s)

API processing | cocrystal formation: suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

cell culture | mammalian: suitable

agency

ChP, Ph. Eur., JP, USP

agency

-

agency

-

agency

meets EP testing specifications, meets USP testing specifications

form

solid

form

-

form

-

form

powder

product line

EMPROVE® EXPERT

product line

-

product line

TraceCERT®

product line

-

pH

7.7 (20 °C, 10 g/L in H2O)

pH

-

pH

-

pH

-


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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

wgk

WGK 1



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