ALD00348

Boc-3-[3,4-bis(trifluoromethyl)phenyl]-L-alanine

≥95% (HPLC)

• Synonym(s): (S)-3-(3,4-Bis(trifluoromethyl)phenyl)-2-(tert-butoxycarbonylamino)propanoic acid
• Empirical Formula (Hill Notation): C₁₆H₁₇F₆NO₄
• CAS Number: 2120095-23-8
• Molecular Weight: 401.30
• UNSPSC Code: 12352209
• PubChem Substance ID: 329772653
• NACRES: NA.22

Properties

• description: ALPH: +24.0, 0.5%EtOH
• Assay: ≥95% (HPLC)
• form: powder or solid
• reaction suitability: reaction type: Boc solid-phase peptide synthesis; reagent type: ligand; reaction type: C-H Activation
• application(s): peptide synthesis
• storage temp.: 2-8°C
• SMILES string: OC([C@@H](NC(OC(C)(C)C)=O)CC1=CC(C(F)(F)F)=C(C(F)(F)F)C=C1)=O
• InChI: 1S/C16H17F6NO4/c1-14(2,3)27-13(26)23-11(12(24)25)7-8-4-5-9(15(17,18)19)10(6-8)16(20,21)22/h4-6,11H,7H2,1-3H3,(H,23,26)(H,24,25)/t11-/m0/s1
• InChI key: LLRXWQAYIGATCH-NSHDSACASA-N

Description

Application

Unnatural amino acid was derived from a C-H Activation methodology developed by Jin-Quan Yu and coworkers. The Pd-mediated C-C bond formation can be made in tandem with 2-Methylpyridine (Aldrich 109835).

Other Notes

Ligand-Controlled C(sp³)–H Arylation and Olefination in Synthesis of Unnatural Chiral α–Amino Acids

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable