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A86406

Sigma-Aldrich

α-Angelica lactone

98%

Synonym(s):

alpha-Angelica lactone, 4-Hydroxy-3-pentenoic acid γ-lactone, 5-Methyl-2(3H)-furanone

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About This Item

Empirical Formula (Hill Notation):
C5H6O2
CAS Number:
591-12-8
Molecular Weight:
98.10
Beilstein:
108394
EC Number:
209-701-8
MDL number:
MFCD00005375
UNSPSC Code:
12352100
PubChem Substance ID:
24891351
NACRES:
NA.22

Assay

98%

form

liquid

refractive index

n20/D 1.448 (lit.)

bp

55-56 °C/12 mmHg (lit.)

mp

13-17 °C (lit.)

density

1.092 g/mL at 25 °C (lit.)

SMILES string

CC1=CCC(=O)O1

InChI

1S/C5H6O2/c1-4-2-3-5(6)7-4/h2H,3H2,1H3

InChI key

QOTQFLOTGBBMEX-UHFFFAOYSA-N

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Related Categories

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

154.4 °F - closed cup

Flash Point(C)

68 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Y M Ioannou et al.
Cancer research, 42(4), 1199-1204 (1982-04-01)
The effects of alpha-angelica lactone (alpha-AL), butylated hydroxyanisole (BHA), and beta-naphthoflavone (beta-NF) on the amount of benzo(alpha)pyrene (BP) metabolite:DNA adducts formed in the forestomach, lung, and liver of ICR/Ha mice were investigated 48 hr after p.o. administration of BP. BP
W A Nijhoff et al.
Carcinogenesis, 16(3), 607-612 (1995-03-01)
The naturally occurring anticarcinogens flavone and alpha-angelicalactone incorporated separately and simultaneously in the diet at 0.5, 0.1, 0.05 and 0.01% w/w, were studied with respect to their effects on oesophageal, gastric, intestinal, colonic and hepatic (i) glutathione S-transferase (GST) enzyme
Xin Huang et al.
Chemical communications (Cambridge, England), 48(18), 2439-2441 (2012-01-24)
The first organocatalytic asymmetric assembly of Morita-Baylis-Hillman carbonates of isatins and α-angelica lactone has been studied, affording multifunctional products containing two valuable pharmacophores and vicinal quaternary chiral centers in high stereoselectivity (up to 92% ee, dr >95:5).
Lin Zhou et al.
Organic letters, 13(12), 3056-3059 (2011-05-21)
A direct highly diastereo- and enantioselective asymmetric vinylogous Mannich-type (AVM) reaction of aldimines with nonactivated natural α-angelica lactone has been successfully developed. It was demonstrated that the nonactivated natural α-angelica lactone is a useful vinylogous nucleophile to give the chiral
Hagai Tavori et al.
Bioorganic & medicinal chemistry, 16(15), 7504-7509 (2008-06-24)
Paraoxonase1 (PON1) is a HDL bound enzyme and many of the anti-atherogenic properties of HDL are attributed to PON1. The enzyme precise mechanism of protective action and its endogenous substrate remain elusive. PON1 hydrolyzes organophosphates, arylesters and lactones, whereas the

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