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Sigma-Aldrich

Acetylated branched polyethylenimine solution

20% acetylation, suitable for biomedical research

Synonym(s):

Acetylated PEI, Acetylated-PEI25K, Capped PEI

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About This Item

Linear Formula:
(C29H63N11O3)mC3H8N2O
UNSPSC Code:
12162002
NACRES:
NA.23

product name

Acetylated branched polyethylenimine solution 20% solution, 20% acetylation, suitable for biomedical research

Quality Level

100

form

liquid

concentration

20 wt. % in water

color

pale yellow to yellow

storage temp.

2-8°C

Related Categories

Application

High molecular weight branched PEI is commonly used in gene delivery due to its high transfection efficiency in a broad range of cells. Branched PEI has been used to successfully deliver genetic material both in vitro and in vivo. N-Acetylation of PEI could lower its toxicity. At low degree of substitution (below 25%) resulted in moderate improvement of transfection activity.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

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Nathan P Gabrielson et al.
Biomacromolecules, 7(8), 2427-2435 (2006-08-15)
We previously reported that gene delivery efficiency of 25-kDa, branched polyethylenimine (PEI) increased upon acetylation of up to 43% of the primary amines with acetic anhydride. In the present work, we investigated the effects of further increasing the degree of
M Laird Forrest et al.
Pharmaceutical research, 21(2), 365-371 (2004-03-23)
Polyethylenimine (PEI) is a highly effective gene delivery vector, but because it is an off-the shelf material, its properties may not be optimal. To investigate the effects of the protonation properties of the polymer, we generated PEI derivatives by acetylating
Arkadi Zintchenko et al.
Bioconjugate chemistry, 19(7), 1448-1455 (2008-06-17)
Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current study, we generated a number of nontoxic derivates of branched PEI through modification of

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