859923
3-Hydroxybenzylhydrazine dihydrochloride
97%
Synonym(s):
α-Hydrazino-m-cresol dihydrochloride, 3-(Hydrazinomethyl)phenol dihydrochloride, NSD-1015
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About This Item
Linear Formula:
HOC6H4CH2NHNH2 · 2HCl
CAS Number:
Molecular Weight:
211.09
Beilstein:
9282965
EC Number:
MDL number:
UNSPSC Code:
12352103
Assay
97%
mp
138-140 °C (lit.)
SMILES string
Cl[H].Cl[H].NNCc1cccc(O)c1
InChI
1S/C7H10N2O.2ClH/c8-9-5-6-2-1-3-7(10)4-6;;/h1-4,9-10H,5,8H2;2*1H
InChI key
ONOJPUDFIOEGCX-UHFFFAOYSA-N
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Application
Inhibitor of aromatic amino acid decarboxylase.
Biochem/physiol Actions
Inhibitor of L-aromatic amino acid decarboxylase; crosses blood brain barrier. Also inhibits GABA aminotransferase, as well as other pyridoxal-phosphate-requiring enzymes, by forming the 3-hydroxybenzylhydrazone of that cofactor.
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Description
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L W Hunter et al.
Biochemical pharmacology, 45(6), 1363-1366 (1993-03-24)
The activity of the enzyme tyrosine hydroxylase (TH; EC 1.14.16.2) is commonly studied indirectly by quantifying the formation of the product, 3,4-dihydroxyphenylalanine (DOPA), after inhibition of aromatic L-amino acid decarboxylase (AAAD; EC 4.1.1.28), the enzyme which metabolizes DOPA. This study
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