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484628

Sigma-Aldrich

Benztropine mesylate

95%

Synonym(s):

Benztropine methanesulfonate

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About This Item

Empirical Formula (Hill Notation):
C21H25NO
CAS Number:
132-17-2
Molecular Weight:
307.43
EC Number:
205-048-8
MDL number:
MFCD00074784
UNSPSC Code:
12352103

Assay

95%

mp

135 °C (lit.)

SMILES string

CS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c3ccccc3)c4ccccc4

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H302,H311 + H331

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
20511TR
13802TR

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Clara Velázquez-Sánchez et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 34(12), 2497-2507 (2009-07-17)
Benztropine (BZT) analogs, a family of high-affinity dopamine transporter ligands, are molecules that exhibit pharmacological and behavioral characteristics predictive of significant therapeutic potential in cocaine addiction. Here, we examined in mice the effects of 3 alpha-[bis(4'-fluorophenyl)metoxy]-tropane (AHN-1055) on motor activity
Su-Min Li et al.
The Journal of pharmacology and experimental therapeutics, 336(2), 575-585 (2010-11-23)
Previous studies suggested that differences between the behavioral effects of cocaine and analogs of benztropine were related to the relatively slow onset of action of the latter compounds. Several N-substituted benztropine analogs with a relatively fast onset of effects were
Clara Velazquez-Sanchez et al.
The international journal of neuropsychopharmacology, 14(5), 655-665 (2010-08-26)
N-substituted benztropine (BZT) analogs are molecules that display high affinity for the dopamine transporter (DAT), therapeutic-like effects in animal models of cocaine abuse, and psychopharmacological characteristics consistent with those of a substitute medication for cocaine addiction. Since amphetamine (Amph) and
Margaret Walshe et al.
The Cochrane database of systematic reviews, 2(2), CD008624-CD008624 (2012-02-18)
Drooling is a common problem for children with cerebral palsy (CP). This can be distressing for these children as well as for their parents and caregivers. The consequences of drooling include risk of social rejection, damp and soiled clothing, unpleasant
Brooke E Schmeichel et al.
Neuropharmacology, 64, 321-328 (2012-07-17)
Drugs used to treat attention deficit hyperactivity disorder (ADHD) improve prefrontal cortex (PFC)-dependent cognitive function. The majority of ADHD-related treatments act either as dual norepinephrine (NE) and dopamine (DA) reuptake inhibitors (psychostimulants) or selective NE reuptake inhibitors (SNRIs). Certain benztropine
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