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215570

Sigma-Aldrich

1,4-Cyclohexanedione mono(2,2-dimethyltrimethylene ketal)

95%

Synonym(s):

3,3-Dimethyl-1,5-dioxaspiro[5.5]undecan-9-one

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About This Item

Empirical Formula (Hill Notation):
C11H18O3
CAS Number:
69225-59-8
Molecular Weight:
198.26
EC Number:
273-918-4
MDL number:
MFCD00006652
UNSPSC Code:
12352100
PubChem Substance ID:
24852904

Assay

95%

form

solid

mp

45-50 °C (lit.)

SMILES string

CC1(C)COC2(CCC(=O)CC2)OC1

InChI

1S/C11H18O3/c1-10(2)7-13-11(14-8-10)5-3-9(12)4-6-11/h3-8H2,1-2H3

InChI key

COKVDTKAWIFNTH-UHFFFAOYSA-N

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Application

1,4-Cyclohexanedione mono(2,2-dimethyltrimethylene ketal) has been used in the synthesis of:
  • 3,4-dihydro-2(1H)-naphthalenones via carbainion induced reaction
  • 8-aryl-5-cyano-6-sec-amino-3,4-dihydro-2(1H)-naphthalenone-(2,2-dimethyltrimethylene)ketals

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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V J Ram et al.
The Journal of organic chemistry, 66(16), 5333-5337 (2001-08-04)
An innovative approach to the one-pot synthesis of highly functionalized 3,4-dihydro-1H-isothiochromenes (3), 6H-benzo[c]thiochromenes (5, 6), 6H-benzo[c]chromenes (8), and 2,3-dihydro-1-benzothiophenes (10, 11) is delineated from the reaction of a suitably functionalized 6-aryl-3-carbomethoxy-4-methylthio-2H-pyran-2-one (1) and a carbanion generated from tetrahydrothiopyran-4-one, 4-thiochromanone, 4-chromanone

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