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Sigma-Aldrich

Methyl 2-chloropropionate

97%

Synonym(s):

(±)-Methyl 2-chloropropionate

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About This Item

Linear Formula:
CH3CHClCOOCH3
CAS Number:
17639-93-9
Molecular Weight:
122.55
Beilstein:
1421535
EC Number:
241-624-5
MDL number:
MFCD00000863
UNSPSC Code:
12352100
PubChem Substance ID:
24848393

vapor density

4.22 (vs air)

vapor pressure

5.25 mmHg ( 20 °C)

Assay

97%

expl. lim.

19 %

refractive index

n20/D 1.417 (lit.)

bp

132-133 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

SMILES string

COC(=O)C(C)Cl

InChI

1S/C4H7ClO2/c1-3(5)4(6)7-2/h3H,1-2H3

InChI key

JLEJCNOTNLZCHQ-UHFFFAOYSA-N

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General description

Methyl 2-chloropropionate is the initiating/catalyst system during the atom transfer radical polymerization of N,N-dimethylacrylamide, N-isopropylacrylamide and N-vinylpyrrolidone.

Application

Methyl 2-chloropropionate was used as initiator during the synthesis of acrylamide homopolymers and acrylamide-N-isopropylacrylamide block copolymers.

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Warning

Hazard Statements

H226,H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

100.4 °F - closed cup

Flash Point(C)

38 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thermal response of narrow-disperse poly (N-isopropylacrylamide) prepared by atom transfer radical polymerization.
Xia Y, et al.
Macromolecules, 38(14), 5937-5943 (2005)
Acrylamide Homopolymers and Acrylamide-N-Isopropylacrylamide Block Copolymers by Atomic Transfer Radical Polymerization in Water.
Wever DAZ, et al.
Macromolecules, 45(10), 4040-4045 (2012)
A I Gurova et al.
Gigiena truda i professional'nye zabolevaniia, (5)(5), 36-38 (1992-01-01)
Reports of MACs for carboxylic acid derivatives as sodium methoxyacetate (SMOA), methyl chlorpropionate (MCP) and acetoacetic ether (AAE). SMOA shows low toxicity, no cumulation and specific action MCP demonstrates moderate toxicity, low cumulation no specific action in concentrations close to
Controllable synthesis of poly (N-vinylpyrrolidone) and its block copolymers by atom transfer radical polymerization.
Lu X, et al.
Polymer, 48(10), 2835-2842 (2007)
J L Rakels et al.
Enzyme and microbial technology, 15(12), 1051-1056 (1993-12-01)
The enantiomeric ratio (E) is commonly used to characterize the enantioselectivity in enzyme-catalyzed kinetic resolution. In this paper this parameter is directly derived from the enantiomeric excess of substrate and product. This is formally more correct than using Chen's equation
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