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Key Documents

SAB1411035

Sigma-Aldrich

Anti-CEP55 antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

Synonym(s):

C10orf3, FLJ10540, URCC6

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 54.1 kDa

species reactivity

human

technique(s)

western blot: 1 μg/mL

NCBI accession no.

NM_018131.3

UniProt accession no.

Q53EZ4

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CEP55(55165)

General description

The gene CEP55 (Centrosomal protein of 55kDa), also referred to as C10orf3, encodes a 464 amino acid containing protein with highest expression in testis and thymus. This coiled-coil protein has a molar mass of 55kDa. The gene is mapped to human chromosome 10q23.33.

Immunogen

CEP55 (NP_060601.2, 1 a.a. ~ 464 a.a) full-length human protein.

Sequence
MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLLVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK

Biochem/physiol Actions

The gene CEP55 (Centrosomal protein of 55kDa) encodes a protein that is found to be localized to the mother centriole during interphase. It plays a crucial role in microtubule nucleation, mitotic exit and cytokinesis. The protein CEP55 also elicits the cell transformation by stimulating the phosphatidylinositol 3′-kinase (PI3K)/AKT pathway. It participates in the regulation of cell-cycle and is found in certain tumor tissues, such as hepatocellular carcinoma and gastric cancer. Additionally, it is also involved in midbody structure during cytokinesis.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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CEP55 contributes to human gastric carcinoma by regulating cell proliferation.
Tao J
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 35, 4389-4399 (2014)
C-H Chen et al.
Oncogene, 26(29), 4272-4283 (2007-01-24)
A significant challenge in the post-genomic era is how to prioritize differentially expressed and uncharacterized novel genes found in hepatocellular carcinoma (HCC) microarray profiling. One such category is cell cycle regulated genes that have only evolved in higher organisms but
Megan Fabbro et al.
Developmental cell, 9(4), 477-488 (2005-10-04)
Centrosomes in mammalian cells have recently been implicated in cytokinesis; however, their role in this process is poorly defined. Here, we describe a human coiled-coil protein, Cep55 (centrosome protein 55 kDa), that localizes to the mother centriole during interphase. Despite

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