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R0635

Sigma-Aldrich

Retinyl Acetate-Water Soluble

BioReagent, suitable for cell culture

Synonym(s):

Retinyl acetate, Retinol Acetate, Vitamin A, Retinol acetate, Vitamin A acetate

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About This Item

Empirical Formula (Hill Notation):
C22H32O2
CAS Number:
127-47-9
Molecular Weight:
328.49
Beilstein:
1915439
MDL number:
MFCD00019413
UNSPSC Code:
12352205
NACRES:
NA.75

biological source

synthetic (organic)

product line

BioReagent

form

powder

technique(s)

cell culture | mammalian: suitable

color

white to light yellow

mp

57-58 °C

solubility

H2O: 400 mg/mL

storage temp.

−20°C

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

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General description

Retinyl acetate does not exists naturally, but is derived from retinol. It is considered to be more chemically stable than retinol. For this reason it serves as a dietary supplement for vitamin A source. Vitamin A is found in food of animal origin especially liver and also present in brightly colored vegetables. Vitamin A is a member of carotene family, which is a key component in plant pigments.

Application

Retinyl Acetate-Water Soluble has been used as a component of culture medium for secretory cells of venom gland among different Viperidae snakes. It has also been used in testis chunk culturing.
Use to study retinoid regulation of cell transformation; cell differentiation and stem cell development.

Biochem/physiol Actions

Retinyl acetate is known to prevent carcinogenic polycyclic hydrocarbon, methylcholanthrene induced morphological transformation.

Packaging

Package size based on retinol acetate content

Formula variant

With a minimum of 3 mg retinol acetate per gram; balance methyl-β-cyclodextrin.

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Description
Pricing

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360D

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Specifications and Criteria for Biochemical Compounds, 1344, 188-188 (1967)
Advanced Nutrition Micronutrie, 23-23 (2018)
Long-term primary culture of secretory cells of Bothrops jararaca venom gland for venom production in vitro
Yamanouye N, et al.
Nature Protocols, 1(6), 2763-2763 (2006)
Biological Responses in Cancer: Progress toward Potential Applications, 2, 62-62 (2013)
Robert E Chapin et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 107(6), 225-242 (2016-12-27)
The last two decades have seen an increasing search for in vitro models that can replace the use of animals for safety testing. We adapted the methods from a recent nonquantitative report of spermatogenesis occurring in ex vivo mouse testis

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