PZ0160
UK-5099
≥98% (HPLC), powder, mitochondrial pyruvate carrier inhibitor
Synonym(s):
2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid, PF-1005023
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About This Item
Empirical Formula (Hill Notation):
C18H12N2O2
CAS Number:
Molecular Weight:
288.30
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Product Name
UK-5099, ≥98% (HPLC)
Assay
≥98% (HPLC)
form
powder
color
yellow to tan
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
OC(=O)\C(=C\c1cn(-c2ccccc2)c3ccccc13)C#N
InChI
1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
InChI key
BIZNHCWFGNKBBZ-JLHYYAGUSA-N
Application
UK-5099 has been used:
- as a mitochondrial pyruvate blocker to reduce pyruvate transportation into mitochondria in Roswell park memorial institute (RPMI) 1640 medium for prostatic cancer cell line culture
- in dimethyl sulfoxide (DMSO) stock, to study the effect of inhibiting pyruvate transport into mitochondria on pro-inflammatory responses in lipopolysaccharide activated macrophages
- in topical treatment in order to study its effect on hair cycle induction in experimental mice
Biochem/physiol Actions
UK-5099 induces lactate generation.
UK-5099 is a potent inhibitor of the mitochondrial pyruvate transporter.
UK-5099 is a potent inhibitor of the mitochondrial pyruvate transporter. In rat heart mitochondria, UK-5099 inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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