PENNA
Penicillin G sodium salt
~1650 U/mg
Synonym(s):
Benzylpenicillin sodium salt
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About This Item
Empirical Formula (Hill Notation):
C16H17N2NaO4S
CAS Number:
Molecular Weight:
356.37
Beilstein:
3834217
EC Number:
MDL number:
UNSPSC Code:
51283424
PubChem Substance ID:
NACRES:
NA.85
Recommended Products
form
powder
specific activity
~1650 U/mg
solubility
H2O: 100 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
[Na+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O
InChI
1S/C16H18N2O4S.Na/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
InChI key
FCPVYOBCFFNJFS-LQDWTQKMSA-M
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General description
Penicillin G is a narrow spectrum antibiotic. It is effective against Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Penicillin G contains β-lactam ring in their chemical structure.
Application
Penicillin G sodium salt has been used:
- to study the diagnostic and therapeutic implications of gentamicin-resistant Enterococcus faecalis sequence type 6 with reduced penicillin susceptibility
- in cell culture alone as well as in combination with streptomycin and other antibiotics
- to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining
Biochem/physiol Actions
Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.
Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.
Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.
Packaging
1mu,10mu,100mu
Caution
Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H2O at 100 mg/mL.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.Product contains Penicillin
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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