O0391

Olopatadine hydrochloride

≥98% (HPLC)

• Synonym(s): (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride, AL-4943A, KW-4679, Opatanol, Patanol
• Empirical Formula (Hill Notation): C₂₁H₂₃NO₃·HCl
• CAS Number: 140462-76-6
• Molecular Weight: 373.87
• MDL number: MFCD00875716
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818840
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• solubility: H₂O: ≥20 mg/mL
• storage temp.: room temp
• SMILES string: Cl.CN(C)CC\C=C1\c2ccccc2COc3ccc(CC(O)=O)cc13
• InChI: 1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
• InChI key: HVRLZEKDTUEKQH-NOILCQHBSA-N
• Gene Information: human ... HRH1(3269)

Description

Biochem/physiol Actions

Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer.

Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limits its brain penetration.

Safety Information

• Pictograms: GHS06,GHS09
• Signal Word: Danger
• Hazard Statements: H301,H400
• Precautionary Statements: P273 - P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable