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Key Documents

M157

Sigma-Aldrich

MEN-10,376

≥95% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C57H68N12O10
CAS Number:
Molecular Weight:
1081.22
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.32

Quality Level

Assay

≥95% (HPLC)

form

solid

color

white

storage temp.

−20°C

SMILES string

CC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(N)CC(O)=O)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CCCCN)C(N)=O

InChI

1S/C57H68N12O10/c1-31(2)50(69-56(78)48(26-35-30-63-43-16-8-5-13-39(35)43)67-53(75)45(23-32-18-20-36(70)21-19-32)65-52(74)40(59)27-49(71)72)57(79)68-47(25-34-29-62-42-15-7-4-12-38(34)42)55(77)66-46(24-33-28-61-41-14-6-3-11-37(33)41)54(76)64-44(51(60)73)17-9-10-22-58/h3-8,11-16,18-21,28-31,40,44-48,50,61-63,70H,9-10,17,22-27,58-59H2,1-2H3,(H2,60,73)(H,64,76)(H,65,74)(H,66,77)(H,67,75)(H,68,79)(H,69,78)(H,71,72)

InChI key

QQHOFZNACVKNHK-UHFFFAOYSA-N

Gene Information

human ... TACR2(6865)

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Amino Acid Sequence

Asp-Tyr-Trp-Val-Trp-Trp-Lys-NH2

Biochem/physiol Actions

Potent and selective NK-2 tachykinin receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Donatella Mutolo et al.
Journal of applied physiology (Bethesda, Md. : 1985), 109(4), 1002-1010 (2010-07-24)
We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) region has a crucial role in determining both the expiratory and inspiratory components
Monika Sundqvist et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 291(4), R1138-R1144 (2006-05-20)
The transparent body wall of Xenopus laevis larvae during the first developmental stages allows in vivo studies of gastrointestinal tract activity. The purpose of this study was to chart the ontogeny of gut motility in Xenopus larvae and to identify
Sean B Dolan et al.
Drug and alcohol dependence, 146, 97-102 (2014-12-08)
Dimethylamylamine (DMAA) is a component of many dietary supplements and has recently been associated with numerous adverse effects, prompting the US military and World Anti-Doping Agency to ban its use as a supplement. The current study aimed to elucidate the
H Liu et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 22(2), 210-216 (2009-09-11)
Intraluminal acid evokes sustained oesophageal longitudinal smooth muscle (LSM) contraction and oesophageal shortening, which may play a role in oesophageal pain and the aetiology of hiatus hernia. In the opossum model, this reflex has been shown to involve mast cell
Kyle M Baumbauer et al.
Behavioral neuroscience, 121(5), 1082-1094 (2007-10-03)
Previous research has demonstrated that spinally transected rats can acquire a prolonged flexion response to prevent the delivery of shock. However, rats that receive shock irrespective of leg position cannot learn to maintain the same response. The present experiments examined

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