I1020
Interleukin-4 from mouse
IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
mIL-4, Interleukin-4 human
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About This Item
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biological source
mouse
recombinant
expressed in E. coli
Assay
≥98% (SDS-PAGE)
form
lyophilized powder
potency
0.1-2.0 ng/mL ED50/EC50
quality
endotoxin tested
mol wt
~13.5 kDa
packaging
pkg of 5 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Il4(16189)
Application
Interleukin-4 from mouse has been used:
- as a component of cell culture media for class switch recombination assay
- to study its therapeutic benefits for mucosal healing
- as a pioglitazone or new peroxisome proliferator-activated receptor agonist (GQ-11)
Biochem/physiol Actions
Interleukin-4 (IL-4) is a lymphokine with profound effects on the growth and differentiation of immunologically competent cells. IL-4 is also known as B cell stimulatory factor-1 (BSF-1), T cell growth factor-2 (TCGF-2) and mast-cell growth factor-2 (MCGF-2). Inhibits VEGF-induced and FGF-Basic-induced angiogenesis. IL-4 is a complex glycoprotein released by a subset of activated T cells. Treatment of IL-4 with specific glycosidases yields an active polypeptide. Human and mouse IL-4 share 50% amino acid sequence homology, but their biological actions are species-specific.
Physical form
Lyophilized, 0.2 μm filtered, with no additives.
Analysis Note
The proliferative activity is tested in culture using mouse HT-2 cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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