Skip to Content
Merck
All Photos(2)

Documents

D0540

Sigma-Aldrich

DNQX

≥98% (TLC)

Synonym(s):

6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C8H4N4O6
CAS Number:
2379-57-9
Molecular Weight:
252.14
MDL number:
MFCD00069257
UNSPSC Code:
51111800
PubChem Substance ID:
24277973
NACRES:
NA.77

Quality Level

200

Assay

≥98% (TLC)

form

powder

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O

InChI

1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)

InChI key

RWVIMCIPOAXUDG-UHFFFAOYSA-N

Gene Information

human ... GRIA1(2890) , GRIA2(2891) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901)
mouse ... Gria1(14799)
rat ... Gria1(50592) , Grik1(29559) , Grik4(24406) , Grin2a(24409)

Application

DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.

Biochem/physiol Actions

DNQX is a quinoxaline derivative.
A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Differential Desensitization Observed at Multiple Effectors of Somatic mu-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity
Fox PD and Hentges ST
The Journal of Neuroscience, 37(36), 8667-8677 (2017)
Rei Yamada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3927-3938 (2013-03-01)
Neurons in the nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs from the nucleus magnocellularis (NM) on both sides and process the interaural time differences (ITDs) for sound localization. Sustained inhibition from the superior olivary nucleus
James M Otis et al.
Neuron, 103(3), 423-431 (2019-06-15)
The paraventricular thalamus (PVT) is an interface for brain reward circuits, with input signals arising from structures, such as prefrontal cortex and hypothalamus, that are broadcast to downstream limbic targets. However, the precise synaptic connectivity, activity, and function of PVT circuitry
The mouse pulvinar nucleus links the lateral extrastriate cortex, striatum, and amygdala
Zhou N, et al.
The Journal of Neuroscience, 38(2), 347-362 (2018)
Andrew R Rau et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(33), 6449-6459 (2019-06-27)
Neuronal circuits regulating hunger and satiety synthesize information encoding the energy state of the animal and translate those signals into motivated behaviors to meet homeostatic needs. Proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus are activated by energy
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service