1.06346

Sodium dihydrogen phosphate monohydrate

for analysis EMSURE^® ACS,Reag. Ph Eur

• Synonym(s): Sodium phosphate monobasic monohydrate, Monosodium phosphate, Sodium dihydrogen phosphate monohydrate
• Linear Formula: NaH₂PO₄ · H₂O
• CAS Number: 10049-21-5
• Molecular Weight: 137.99
• MDL number: MFCD00149208
• UNSPSC Code: 12352302
• EC Index Number: 231-449-2
• NACRES: NA.21

Properties

• grade: ACS reagent
• Quality Level: 300
• Agency: reag. Ph. Eur.
• product line: EMSURE^®
• Assay: 99.0-102.0% (alkalimetric)
• form: crystals
• potency: >2000 mg/kg LD₅₀, oral (Rat); >7940 mg/kg LD₅₀, skin (Rabbit)
• impurities: ≤0.01% Insoluble matter
• pH: 4.1-4.5 (25 °C, 50 g/L in H₂O)
• solubility: 850 g/L
• density: 2.04 g/cm³ at 20 °C
• bulk density: 880 kg/m³
• anion traces: chloride (Cl^-): ≤0.0005%; sulfate (SO₄^2-): ≤0.003%
• cation traces: Ca: ≤0.005%; Fe: ≤0.0005%; K: ≤0.005%; N: ≤0.001%; heavy metals: ≤0.0005%
• UV absorption: λ: 280 nm A_max: ≤0.05
• storage temp.: 2-30°C
• SMILES string: [Na+].[H]O[H].OP(O)([O-])=O
• InChI: 1S/Na.H3O4P.H2O/c;1-5(2,3)4;/h;(H3,1,2,3,4);1H2/q+1;;/p-1
• InChI key: BBMHARZCALWXSL-UHFFFAOYSA-M

Description

Application

• Development of a multiparticulate drug delivery system for in situ amorphisation.: This study explores the use of sodium dihydrogen phosphate monohydrate in developing a multiparticulate drug delivery system. The research highlights the compound′s role in achieving in situ amorphisation, enhancing drug solubility and bioavailability (Holm TP et al., 2022).


• Metabolomic characterization of rhubarb species by capillary electrophoresis and ultra-high-pressure liquid chromatography.: Sodium dihydrogen phosphate monohydrate is utilized in the buffer system for capillary electrophoresis and UHPLC, aiding in the metabolomic analysis of rhubarb species. This research underscores its importance in improving separation efficiency and resolution in analytical methods (Tseng YJ et al., 2013).

Linkage

Replaces: SX0709; SX0709-5; SX0710; SX0710-1; SX0710-3; SX0710-5; SX0710-20

Analysis Note

Assay (alkalimetric): 99.0 - 102.0 %
Insoluble matter: ≤ 0.01 %
pH-value (5 %; water, 25 °C): 4.1 - 4.5
UV absorption (280 nm; 1 mol/l; 1 cm; water): ≤ 0.05
Chloride (Cl): ≤ 0.0005 %
Sulfate (SO₄): ≤ 0.003 %
Total nitrogen (N): ≤ 0.001 %
Heavy metals (ACS): ≤ 0.0005 %
Ca (Calcium): ≤ 0.005 %
Fe (Iron): ≤ 0.0005 %
K (Potassium): ≤ 0.005 %
Corresponds to ACS,Reag. Ph Eur

Legal Information

EMSURE is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable