927562
MSOD-alkyne
≥95%
Synonym(s):
2-(Methylsulfonyl)-5-(4-(prop-2-yn-1-yloxy)phenyl)-1,3,4-oxadiazole
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About This Item
Empirical Formula (Hill Notation):
C12H10N2O4S
CAS Number:
Molecular Weight:
278.28
UNSPSC Code:
12352101
NACRES:
NA.22
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Application
MSOD-alkyne is a probe that can be used to label cysteines through nucleophilic aromatic substitution. A method was developed using cysteine-reactive compounds including this one to allow for unbiased analysis of proteomic data in quantitative applications . The method uses light or heavy labeling with the isotopically labelled desthiobiotin azide (isoDTB) tag for mass spectrometry analysis . Analysis then uses the isotopic tandem orthogonal proteolysis activity-based protein profiling (isoTOP-ABPP) workflow .
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome
Zanon, et al
Angewandte Chemie (International Edition in English), 2829-2836 (2020)
Profiling the proteome-wide selectivity of diverse electrophiles
Zanon, et al
ChemRxiv : the preprint server for chemistry (2021)
Eranthie Weerapana et al.
Nature, 468(7325), 790-795 (2010-11-19)
Cysteine is the most intrinsically nucleophilic amino acid in proteins, where its reactivity is tuned to perform diverse biochemical functions. The absence of a consensus sequence that defines functional cysteines in proteins has hindered their discovery and characterization. Here we
Keriann M Backus et al.
Nature, 534(7608), 570-574 (2016-06-17)
Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes are considered 'undruggable'. Fragment-based ligand discovery can identify small-molecule probes for proteins
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